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There may be sizeable dialogue from the literature pertaining to endotoxicity as opposed to pyrogenicity. Lots of the FDA investigators and reviewers of inspection stories are unaware of the constraints on the USP rabbit examination as an endotoxin test. For example, Elin, in the Annual Evaluation of Drugs, commented that "The recurring administration of lipopolysaccharide (LPS), the chemical title utilized synonymously with bacterial endotoxins, to experimental animals results in a progressive diminution of many of the Organic effects, Primarily fever.
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